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Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing. While these pathogenetic changes are well described individually, collective mechanisms are lacking. To measure these responses we have developed and implemented a suite of novel cell and tissue biomechanical tools. Research Interests: Biomechanics of the Airway and Vasculature. This study characterizes the mechanical properties of primary cultures of the human Schlemm Canal SC endothelial cell, and for the first time, the scope of their changes in response to pharmacological agents that are known to modulate outflow resistance in the aqueous humour. The first, bronchoconstriction, occurs as a result of increased contraction of the airway smooth muscle ASM cell. Such mechanisms not only advance our understanding of asthma but also make accessible new pathways for therapeutic intervention. In press.

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    JoVE Peer Reviewed Scientific Video Journal Methods and Protocols

    Facebook Director · Muscat, Oman.
    Whereas the reinforcement response is known to be mediated by upstream mechanosensing and downstream signaling, results presented here show the fluidization response to be altogether novel: it is a direct physical effect of mechanical force acting upon a structural lattice that is soft and fragile.

    While these pathogenetic changes are well described individually, collective mechanisms are lacking. A major cause of morbidity and mortality in critically ill patients is acute lung injury ALI and acute respiratory distress syndrome ARDS. Ramaswamy Krishnan earned a Ph.

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    The pathogenesis of asthma involves three major changes that contribute ultimately to excessive narrowing of the airway. These new findings firmly establish the SC endothelial cell as a reactive but variable mechanical component of the aqueous humour outflow pathway in the eye.

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    Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing.

    images ramaswamy krishnan omani
    Ramaswamy krishnan omani
    Such mechanisms not only advance our understanding of asthma but also make accessible new pathways for therapeutic intervention.

    In press. Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness. This study characterizes the mechanical properties of primary cultures of the human Schlemm Canal SC endothelial cell, and for the first time, the scope of their changes in response to pharmacological agents that are known to modulate outflow resistance in the aqueous humour.

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    PLoS One, 4 5 :e Accordingly, we seek new mechanisms formulated on the basis of physical and biochemical measurements of contractility, stretch, and remodeling in primary ASM cell cultures and in intact airways within precision cut human lung slices.

    Ramaswamy Krishnan million organization with varied interests in trading, contracting, projects and manufacturing and employee strength of 1, +. Oman​. Ram-Mohan S, Bai Y, Schaible N, Ehrlicher AJ, Cook DP, Suki B, Stoltz DA, Solway J, Ai X, Krishnan R.

    Tissue traction microscopy to quantify muscle contraction. Basic Research - My laboratory investigates mechanosensing responses in the lung and beyond.

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    To measure these responses we have developed and.
    Accordingly, we seek new mechanisms formulated on the basis of physical and biochemical measurements of contractility, stretch, and remodeling in primary ASM cell cultures and in intact airways within precision cut human lung slices. This study characterizes the mechanical properties of primary cultures of the human Schlemm Canal SC endothelial cell, and for the first time, the scope of their changes in response to pharmacological agents that are known to modulate outflow resistance in the aqueous humour.

    PLoS One, 4 5 :e Am J Physiol Cell Physiol.

    images ramaswamy krishnan omani

    To elucidate these mechanisms, we focus on the underlying role of physical forces.

    images ramaswamy krishnan omani
    COCONUT TABLATURE
    Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing.

    Masader – Oman Virtual Science Library

    Using a novel nanotechnology, this study shows that in loading conditions expected in most physiological circumstances the well-known localized cellular stretch response called reinforcement is trumped by the newly discovered global cellular stretch response called fluidization.

    Ramaswamy Krishnan earned a Ph. PLoS One, 4 5 :e In press. Such forces arise from contractile forces within the EC, tugging forces between adjacent ECs, passive matrix distensibility, and active matrix stretch Acute airway narrowing in asthma.

    Whereas the reinforcement response is known to be mediated by upstream mechanosensing and downstream signaling, results presented here show the fluidization response to be altogether novel: it is a direct physical effect of mechanical force acting upon a structural lattice that is soft and fragile.

    2 thoughts on “Ramaswamy krishnan omani

    1. This study characterizes the mechanical properties of primary cultures of the human Schlemm Canal SC endothelial cell, and for the first time, the scope of their changes in response to pharmacological agents that are known to modulate outflow resistance in the aqueous humour. A major cause of morbidity and mortality in critically ill patients is acute lung injury ALI and acute respiratory distress syndrome ARDS.

    2. Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces.