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Length: 4. For this reason, we continued with the optimization of the reaction conditions using this enzyme. All experiments were carried out in duplicate. Generation of aptamers with an expanded chemical repertoire. Gold L. To whom correspondence should be addressed. We need to integrate the knowledge and skills from different disciplines and from communities all over the world to enable effective responses to future epidemics.

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  • Health care Nature
  • Transdisciplinarity Joint Problem Solving among Science, Technology, and Society SpringerLink
  • الويبو البحث في مجموعات البراءات الدولية والوطنية

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    Synthesis of altritol nucleoside phosphoramidites for oligonucleotide synthesis.

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    Skip to main content. Afterwards the oligonucleotides were lyophilized and resuspended in Milli-Q water. Park C.

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    Nature Research menu. DryjaM. Combination therapy with the anti-HIV-1 monoclonal antibodies 3BNC and maintains long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.

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    Synthesis of altritol nucleoside phosphoramidites for oligonucleotide synthesis.

    Health care Nature

    Letter 27 March Longer human lives have led to a global burden of late-life disease, and so interventions, including changes to lifestyle and medical innovations, are needed to prevent disease and increase late-life health.

    A high-resolution, global atlas of mortality of children under five years of age between and highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

    Letter 16 May Diafa S. The synthesis and evaluation of new, hypermodified nucleotides is necessary to advance the field of aptamer therapeutics and diagnostics as only by increasing the number of available aptamer chemistries, we can gain knowledge on the attributes that are essential for success.

    The firm of Gladstone & Weissman has its beginnings in the career of Peter Gladstone, who, in the early part of his career, worked under the.

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    Transdisciplinarity Joint Problem Solving among Science, Technology, and Society SpringerLink

    Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases. Marleen Renders, Shrinivas Dumbre, [.
    A Schematic presentation of the modified nucleotides used in this study, 1a—fB the aryl R moieties in 1a—f. Fellouse F. Data were recorded using Octet Data Acquisition 8.

    الويبو البحث في مجموعات البراءات الدولية والوطنية

    MF3 came with a 5-speed manual transmission as basic, and a 6-speed sequential gearbox as an option. The nucleotide 1f was obtained from nucleotide 1e by transfer hydrogenolysis catalyzed by palladium on carbon in cyclohexene. Schermerhorn K.

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    The control reaction in which the template strand is omitted, is shown in Supplementary Figure S4.

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    Search Article search Search. Letter 27 March Open Access Mapping changes in housing in sub-Saharan Africa from to The prevalence of improved housing with improved drinking water and sanitation, sufficient living area and durable construction in urban and rural sub-Saharan Africa doubled between and Probing ambiguous base-pairs by genetic transformation with XNA templates.

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    1. A strategy developed to define off-target effects of gene-editing nucleases in whole organisms is validated and leveraged to show that CRISPR—Cas9 nucleases can be used effectively in vivo without inducing detectable off-target mutations. Search Article search Search.