Antigen processing is an immunological process that prepares antigens for presentation to . Mycobacterium tuberculosis phagosome. Molecular microbiology, 31(6), Chicago. Richard A. Goldsby; et al. . Immunology (5th ed.). Kuby Immunology / Edition 7. Add to Wishlist. ISBN X; ISBN ; Pub. Date: 01/25/; Publisher: Freeman. Kuby Immunology | Thomas J. Kindt, Richard A. Goldsby, Barbara A. Osborne, Janis Kuby | ISBN: | Kostenloser Versand für alle Bücher mit.
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Worn out proteins within the cell become ubiquitinatedmarking them for proteasome degradation.
Proteasomes break the protein up into peptides that include some around nine amino acids long suitable for fitting within the peptide binding cleft of MHC class I molecules. Transporter associated with antigen processing TAPa immunology by kuby that spans the membrane of the rough endoplasmic reticulumtransports the peptides into the lumen of the rough endoplasmic reticulum ER.
The partially folded MHC class I molecule then interacts with TAP via tapasin the complete complex also contains calreticulin and Erp57 and, in mice, calnexin. Once the peptide is transported into the ER lumen it binds to the cleft of the awaiting Immunology by kuby class I molecule, stabilizing the MHC and allowing it to be transported to the cell surface by the golgi apparatus.
Kuby Immunology by Owen, Judy/ Punt, Jenni/ Stranford, Sharon
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