Monostotic and polyostotic forms usually begins in the second decade of life. • Slow, painless expansion of the jaws. • Patients may complain of swelling or have. Fibro Osseous Lesions. 1. FIBRO-OSSEOUS LESIONS “The term fibro-osseous lesion (FOL) is a generic designation of a group of jaw. Fibro osseous lesions (FOLs) are a generic designation of poorly defined group of lesions which are recognized to affect the jaws and the.


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Reactive, neoplastic, developmental and dysplastic pathologic processes are subsumed under the rubric of BFOL and treatment varies from disease to disease. This review will discuss the clinical, microscopic and imaging aspects of BFOL of the craniofacial complex with updated information on underlying molecular pathogenetic mechanisms of disease.

Whereas some investigators include giant cell lesions of bone with BFOL, lesions of this nature will not be included here with the exception of the trabecular variant of Ossifying Fibroma which is essentially a BFOL yet may contain foci of multinucleated giant cells. However, it has fibro osseous lesions of jaws reported that the progression of FD may continue during adulthood, resulting in facial deformity and functional problems [ 10 — 12 ].

Benign Fibro-Osseous Lesions of the Craniofacial Complex A Review

In contrast, OF requires surgical interventions such as complete enucleation from the surrounding bone because of its growth pattern and risk for recurrence [ 9 ]. Typical cases of FD and OF can be distinguished by radiological fibro osseous lesions of jaws.

In contrast, accurate histopathological distinctions between FD and OF are often difficult unless the alpha subunit of the stimulatory G protein gene GNAS mutation analysis is performed [ 913 ].

As mentioned above, there are difficulties in diagnosing fibro-osseous legions.


This retrospective study primarily intended to show the discrepancy between the radiological and histopathological diagnosis of fibro-osseous legions of the jaws. In addition, we also quantified the potential risk of infection to fibro-osseous legions.

We excluded patients who did not undergo histopathological examination.

Fibro-osseous lesions of the oral and maxillo-facial region: Retrospective analysis for 20 years

Histopathologically, stroma was fibrocellular in many cases of COF, whereas most FDs showed fibrous stroma, interspersed with mainly woven bone. All are characterized by the replacement of bone by cellular fibrous tissue containing foci of mineralization that vary in amount and appearance.

These patients were treated for FOL, reported to the hospital between and The clinical parameters included were age, sex, location, duration, family history, associated symptoms, and behavior of the lesion. The radiographic appearance, histologic features, fibro osseous lesions of jaws, and follow-up data were also recorded.

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Regarding site distribution, the maxilla was divided into two anatomic regions as anterior midline to distal surface of canine and posterior mesial surface of first premolar distally.

The trabeculae assume bizarre shapes linked to Chinese character [8] which was noted in case 2.

Histology of case 1 showed lamellated trabeculae with osteoblastic rimming and minimal fibrous tissue components resembling COF, but the radiographs depicted a homogenous radiopacity with no clear demarcation from the surrounding bone which was in favor of FD.

Correlating the clinical, radiographic and histological findings the final diagnosis of case 1 and 2 was solitary monostotic FD.

FD presents as a poorly fibro osseous lesions of jaws lesion, diffuse and blends with the surrounding bone with characteristic ground glass appearance whereas COF are usually well defined, and they occasionally have a soft-tissue capsule. Other entities fibro osseous lesions of jaws may be confused with FD are COD, Pagets disease, cementoma, cherubism, hyperparathyroidism, chronic sclerosing osteomyelitis, and osteogenic sarcoma, etc.